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A small number of patients with psychiatric illness should receive the lowest possible dose of paroxetine (Paxil).

Patients should be monitored and observed for worsening of their psychiatric symptoms.

Patients should receive at least 2 days of treatment with paroxetine.

A minimum of 10 patients on paroxetine, with at least one other drug that can cause an increase in the risk of suicidal ideation, and an increase in the risk of suicide are recommended. Patients should continue treatment with paroxetine at the lowest possible dose, for at least 5 consecutive days.

Paxil is indicated for the treatment of refractory depression, obsessive-compulsive disorder, and major depressive disorder, but there is no data on its use in patients with a mental disorder that is not responsive to paroxetine.

The lowest possible dosage of paroxetine for a given age of the patient is recommended. Patients should be monitored during the period from the date of first dose to the date of the first dose of paroxetine. The maximum allowed dosage is 1,400 mg per day.

Patients should be observed regularly for worsening of their psychiatric symptoms. The risk of suicide may be increased by taking paroxetine with at least 2 days of treatment with levothyroxine.

Patients should continue treatment with paroxetine at the lowest possible dosage, for at least 5 consecutive days.

The most commonly reported adverse reactions for paroxetine include:

  • nausea, vomiting, and diarrhea
  • dry mouth, constipation, and dizziness
  • headache

Paroxetine is not a controlled substance. Patients should stop taking paroxetine at the lowest dose and the next dose should be prescribed.

The information provided herein is intended to serve as a guide only and should NOT be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you have any doubts or questions about a medical condition, please speak with your doctor or pharmacist.

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The content on this page is for informational purposes only and not a substitute for professional medical advice, diagnosis, or treatment.

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To report an overdose, contact poison control center. Call 1-800-222-1222.

Paxil (paroxetine) is a prescription medication that belongs to a class of drugs called selective serotonin reuptake inhibitors. It works by increasing the levels of a chemical called serotonin, which is responsible for regulating mood and behavior. Paxil is prescribed in two forms: oral tablet and injection. The oral form is available only by prescription. Paroxetine is an antidepressant that is used to treat depression, a disorder in which the brain is unable to process dopamine, a neurotransmitter that is involved in mood regulation. It helps to regulate the levels of dopamine in the brain and is usually prescribed for as long as patients are taking the medication.

Paxil is not approved for the treatment of any other conditions.

1. Introduction

Paxil (paroxetine) is the most commonly used antidepressant in clinical practice and has been approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) and the treatment of panic disorder (PD) in adults [

,

]. However, the approval of this drug for MDD and PD is not currently available, and the treatment for these disorders is generally not approved by the FDA. In the US, the National Institute for Clinical Excellence (NICE) guidelines recommend the use of paroxetine hydrochloride (paroxetine) for the treatment of MDD and PD in adults [

In addition, it is recommended to use a combination of paroxetine with other antidepressants including fluoxetine and fluvoxamine [

], or selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa) [

], escitalopram (Lexapro) [

], fluoxetine and paroxetine (Paxil®) [

], and fluvoxamine (Luvox®) [

In a study of adults with MDD who were treated with paroxetine, patients with MDD had a lower mean risk of hospitalizations for severe depression compared with those who were treated with placebo [

Additionally, the prevalence of comorbidities (including anxiety, anxiety disorders, and depression) in the general population increased with age, with some patients reporting increased anxiety symptoms [

In addition, the efficacy of SSRIs has been investigated in adult patients with MDD who are treated with paroxetine [

It is also worth noting that, in a meta-analysis of randomized controlled trials of SSRIs in adults with MDD, SSRIs were associated with an increased risk of major depressive disorder, generalized anxiety disorder, and social anxiety disorder [

In addition, it has been suggested that paroxetine may be more effective in patients with MDD and PD compared to placebo [

In addition, a previous meta-analysis demonstrated that paroxetine may be an effective treatment option for MDD and PD in adults, with a greater risk of developing depression and anxiety in the presence of a comorbid diagnosis of depression [

In addition, SSRIs may be effective in the treatment of MDD and PD, and this is especially important for patients with comorbid anxiety disorder (e.g., panic disorder, social anxiety disorder) and depression [

Although the safety of paroxetine in the treatment of MDD and PD has not yet been established, paroxetine has been found to be safe and well-tolerated in clinical trials. In clinical trials of paroxetine, the most common adverse reactions in patients with MDD and PD were nausea, vomiting, diarrhea, insomnia, somnolence, dizziness, insomnia, tremor, and anxiety. In the studies of paroxetine, the most common adverse reactions in patients with MDD and PD were nausea, vomiting, diarrhea, insomnia, tremor, and tremor-like symptoms [

Therefore, paroxetine is likely to be effective in the treatment of MDD and PD.

A meta-analysis of 8 randomized controlled trials (RCTs) of paroxetine compared with placebo in MDD and PD, in which paroxetine was compared to placebo in MDD and PD, found that paroxetine reduced the number of new-onset depression symptoms in the MDD group compared to the placebo group [

In addition, paroxetine was found to have a greater risk of suicidal ideation compared with placebo in the MDD group [

Paroxetine was also found to have a greater risk of suicidal ideation compared to placebo in the PD group [

Alternate Name:Brisdelle

Description:Paxil CR is an antidepressant prescribed for the treatment of depression, anxiety disorders, and certain other conditions. The generic alternative is Paroxetine ER. The average Paxil CR cash pricing tends to be near $226 for a supply of 30, 20 mg Paxil CR controlled-release tablets. You can lower your Paxil cost by using our free Paxil CR coupon when you fill your prescription at a participating pharmacy near you.

Dosage Form:Tablet Extended Release 24 Hour

Administration Route:By mouth

Drug Class:Antidepressant, Central Nervous System Agent

Generic Available:Yes

Strength:25 MG

Warnings:It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, sexual problems, glaucoma, or a history of epilepsy or seizures. For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts. This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsIncreased risk of broken bonesSexual problems Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. This medicine may decrease the amount of sperm men make and affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Keep all medicine out of the reach of children. Never share your medicine with anyone.

Food Warnings:Do not use paroxetine and an MAO inhibitor (including isocarboxazid, linezolid, methylene blue, phenelzine, selegiline, tranylcypromine) within 14 days of each other. Do not use this medicine if you are using pimozide or thioridazine., Some medicines can affect how paroxetine works. Tell your doctor if you are using any of the following: Amitriptyline, atomoxetine, cimetidine, dextromethorphan, digoxin, fentanyl, fosamprenavir/ritonavir, meperidine, methadone, metoprolol, nebivolol, phenobarbital, phenytoin, procyclidine, risperidone, St John's wort, tamoxifen, theophylline, tolterodine, tramadolAmphetaminesBlood thinner (including clopidogrel, heparin, warfarin)Diuretic (water pill)Medicine for heart rhythm problems (including encainide, flecainide, propafenone, quinidine)NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Other medicine for depression or anxiety (including buspirone, desipramine, fluoxetine, imipramine, lithium, nortriptyline, venlafaxine)Phenothiazine medicine (including chlorpromazine, perphenazine, prochlorperazine, promethazine)Triptan medicine for migraine headachesTryptophan supplements, Do not drink alcohol while you are using this medicine., This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Low sodium levels in the bloodHigher risk of bleeding problemsHigher risk of broken bones, Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely., This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you., Keep all medicine out of the reach of children.

Read the enclosed leaflet about Paxil CR and any other products that may be available.

What is Paxil?

Paxil, also known by its generic name paroxetine, is a selective serotonin reuptake inhibitor (SSRI) that is used to treat depression and anxiety. It is prescribed to treat a variety of mental and emotional conditions, including obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, and posttraumatic stress disorder.

It works by helping to restore the balance of natural chemicals in the brain, which are responsible for regulating mood. This is a vital part of regulating your body's functions and helps you feel calmer and more relaxed.

This drug has been shown to significantly reduce the symptoms of depression and anxiety, as well as improving overall well-being and quality of life. Paxil is sometimes prescribed for people with, a condition that can affect their mood and ability to control their emotions.

Paxil is a type of antidepressant called a selective serotonin reuptake inhibitor. It works by increasing the levels of serotonin in the brain, which helps to regulate mood. This drug is used to treat depression and anxiety, as well as other conditions.

Paxil is also sometimes used to treat anxiety and obsessive-compulsive disorder (OCD), as well as for panic disorder.

It is sometimes used for depression. Paxil may also be used to treat other conditions, such as post-traumatic stress disorder (PTSD), in which the brain’s serotonin levels are elevated and the symptoms of depression and anxiety become less severe.

Paxil works differently in different people, and is usually prescribed for people with different types of depression and anxiety. It is also used in people who have conditions such as bipolar disorder, or a mental illness that causes mood changes.

The most common side effects of Paxil are drowsiness, dry mouth, and increased sweating. This can be a sign of an overdose, and can cause confusion and difficulty falling or staying asleep. If you experience any of these side effects, you should stop taking the medication and seek immediate medical attention.

How does Paxil work?

Paxil belongs to a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing the levels of serotonin in the brain, which helps to regulate mood. This can help to improve mood, sleep, and energy levels.

Paxil is a type of antidepressant that has been found to be helpful in treating depression, but is sometimes used off-label to treat anxiety and panic disorder.

It is usually prescribed in combination with other medications such as, or.

How to take Paxil?

The typical dose of Paxil is one tablet a day, taken by mouth with food. However, some people may need to take it in the morning.

It is important to follow the instructions provided by your doctor on how to take Paxil.

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